2. Anti-infection Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Fungal Apoptosis Phospholipase Reactive Oxygen Species
  4. Melittin free acid

Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways.

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Melittin free acid Chemical Structure

Melittin free acid Chemical Structure

CAS No. : 123168-46-7

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Melittin free acid Related Antibodies

Top Publications Citing Use of Products

    Melittin free acid purchased from MedChemExpress. Usage Cited in: J Pharm Pharmacol. 2023 Mar 26;rgad008.  [Abstract]

    Melittin (2.5, 5, 10 μg/mL; 48 h) downregulates the expression of Bcl-2, and increases the levels of the pro-apoptotic molecules Bax and cyt-c, in SW480 cells.

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    Description

    Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].

    In Vitro

    Melittin free acid stimulates the biosynthesis of prostaglandins by mouse transformed fibroblasts (MC5-5), human fibroblasts (D550), rabbit aorta endothelial cells (CLO), rat lung type II alveolar pneumocytes (L-2) and rabbit smooth muscle cells (R-I)[1].
    Melittin free acid stimulates the release of arachidonic acid from the cellular phospholipids of MC5-5 cells[1].
    Melittin free acid induces the accumulation of ROS in germinating conidia of A. flavus[2].
    Melittin free acid inhibits B. cinerea MUCL 30158 and CECT 2100 strains with IC50 values of 3.1 and 24 μM, respectively[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Melittin free acid Related Antibodies
    In Vivo

    Melittin (intraperitoneal inoculation) increases 13,14-dihydro-15-keto-PGE2 levels in peripheral blood of mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    2847.45

    Formula

    C131H228N38O32
    CAS No.
    Sequence Shortening

    GIGAVLKVLTTGLPALISWIKRKRQQ
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Melittin free acid Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Melittin123168-46-7FungalApoptosisPhospholipaseReactive Oxygen SpeciespolypeptideantifungalapoptosisMC5-5ROSbroad-spectrumInhibitorinhibitorinhibit

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