1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Others
  2. Histamine Receptor Isotope-Labeled Compounds
  3. Mequitazine-d8 hydrobromide

Mequitazine-d8 hydrobromide  (Synonyms: LM-209-d8 hydrobromide)

Cat. No.: HY-B2168S
Handling Instructions

Mequitazine-d8 hydrobromide is deuterated labeled Mequitazine (HY-B2168). Mequitazine is a potent, and long-acting histamine H1 antagonist.

For research use only. We do not sell to patients.

Mequitazine-d<sub>8</sub> hydrobromide Chemical Structure

Mequitazine-d8 hydrobromide Chemical Structure

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Description

Mequitazine-d8 hydrobromide is deuterated labeled Mequitazine (HY-B2168). Mequitazine is a potent, and long-acting histamine H1 antagonist.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Mequitazine is a potent H1-receptors selective antihistaminic drug widely studied and used for allergic disorders such as hay fever and urticaria[2]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mequitazine and clemizole antagonize the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity[4]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

411.43

Formula

C20H15D8BrN2S

Unlabeled CAS

29216-28-2

SMILES

[2H]C1=C([2H])C([2H])=C2SC3=C(C([2H])=C([2H])C([2H])=C3[2H])N(CC4CN5CCC4CC5)C2=C1[2H].Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mequitazine-d8 hydrobromide
Cat. No.:
HY-B2168S
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