Met-Enkephalin-Arg-Phe

Cat. No.: HY-P4196: FAQs
Data Sheet Handling Instructions

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Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity.

For research use only. We do not sell to patients.

Met-Enkephalin-Arg-Phe Chemical Structure

CAS No. : 73024-95-0

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity^[1].

In Vivo

Met-Enkephalin-Arg-Phe (10-100 nmol/mouse; i.c.v.; once) shows analgesic activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Swiss Webster mice^[1]
Dosage:	10-100 nmol/mouse
Administration:	Intracerebralventricular injection, once
Result:	Produced a dose-related inhibition of the tail-flick response. The effects peaked at 2-4 min and were dissipated by 10 min. The EC₅₀ was 38.5 nmol/mouse.

Molecular Weight

877.02

Formula

C₄₂H₅₆N₁₀O₉S

CAS No.

73024-95-0

Sequence

Tyr-Gly-Gly-Phe-Met-Arg-Phe

Sequence Shortening

YGGFMRF

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Inturrisi CE, et al. Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4. [Content Brief]