2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. [Met5]-Enkephalin, amide TFA

[Met5]-Enkephalin, amide TFA  (Synonyms: 5-Methionine-enkephalin amide TFA)

Cat. No.: HY-P1467A Purity: 99.58%
SDS COA Handling Instructions

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[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Met5]-Enkephalin, amide TFA Chemical Structure

[Met5]-Enkephalin, amide TFA Chemical Structure

CAS No. : 2918768-28-0

Size Price Stock Quantity
5 mg USD 38 In-stock
10 mg USD 60 In-stock
25 mg USD 120 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of [Met5]-Enkephalin, amide TFA:

[Met5]-Enkephalin, amide TFA Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

View All Isoforms
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

IC50 & Target

δ Opioid Receptor/DOR

 

In Vitro

[Met5]-Enkephalin at 0.1 nM, 10 nM, and? 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Met5]-Enkephalin, amide TFA Related Antibodies
Molecular Weight

686.70

Formula

C29H37F3N6O8S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Gly-Gly-Phe-Met-NH2
Sequence Shortening

YGGFM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (145.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2812 mL 14.5624 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (72.81 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.58%

SDS (252 KB)

COA (248 KB) RP-HPLC (113 KB) MS (205 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4562 mL 7.2812 mL 14.5624 mL 36.4060 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL 7.2812 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL 3.6406 mL
15 mM 0.0971 mL 0.4854 mL 0.9708 mL 2.4271 mL
20 mM 0.0728 mL 0.3641 mL 0.7281 mL 1.8203 mL
25 mM 0.0582 mL 0.2912 mL 0.5825 mL 1.4562 mL
30 mM 0.0485 mL 0.2427 mL 0.4854 mL 1.2135 mL
40 mM 0.0364 mL 0.1820 mL 0.3641 mL 0.9101 mL
50 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.7281 mL
60 mM 0.0243 mL 0.1214 mL 0.2427 mL 0.6068 mL
80 mM 0.0182 mL 0.0910 mL 0.1820 mL 0.4551 mL
100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.3641 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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[Met5]-Enkephalin, amide TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Met5]-Enkephalin, amide2918768-28-05-Methionine-enkephalin amideOpioid ReceptorInhibitorinhibitorinhibit

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