2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Methyl clofenapate

Methyl clofenapate  (Synonyms: Clofenapate methyl ester; MCP)

Cat. No.: HY-164082 Purity: 99.04%
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Methyl clofenapate (Clofenapate methyl ester; MCP) is a peroxisome proliferator, which can induce hypolipidemia, peroxisome proliferation, and hepatocarcinogenesis.

For research use only. We do not sell to patients.

Methyl clofenapate Chemical Structure

Methyl clofenapate Chemical Structure

CAS No. : 21340-68-1

Size Price Stock Quantity
5 mg USD 70 In-stock
10 mg USD 113 In-stock
25 mg USD 226 In-stock
50 mg USD 362 In-stock
100 mg USD 580 In-stock
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Based on 1 publication(s) in Google Scholar

Methyl clofenapate Related Antibodies

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Description

Methyl clofenapate (Clofenapate methyl ester; MCP) is a peroxisome proliferator, which can induce hypolipidemia, peroxisome proliferation, and hepatocarcinogenesis[1].

Molecular Weight

304.77

Formula

C17H17ClO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C)(C)OC1=CC=C(C2=CC=C(Cl)C=C2)C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (328.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2812 mL 16.4058 mL 32.8116 mL
5 mM 0.6562 mL 3.2812 mL 6.5623 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 5 mg/mL (16.41 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    This protocol yields a clear solution of 5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2812 mL 16.4058 mL 32.8116 mL 82.0291 mL
5 mM 0.6562 mL 3.2812 mL 6.5623 mL 16.4058 mL
10 mM 0.3281 mL 1.6406 mL 3.2812 mL 8.2029 mL
15 mM 0.2187 mL 1.0937 mL 2.1874 mL 5.4686 mL
20 mM 0.1641 mL 0.8203 mL 1.6406 mL 4.1015 mL
25 mM 0.1312 mL 0.6562 mL 1.3125 mL 3.2812 mL
30 mM 0.1094 mL 0.5469 mL 1.0937 mL 2.7343 mL
40 mM 0.0820 mL 0.4101 mL 0.8203 mL 2.0507 mL
50 mM 0.0656 mL 0.3281 mL 0.6562 mL 1.6406 mL
60 mM 0.0547 mL 0.2734 mL 0.5469 mL 1.3672 mL
80 mM 0.0410 mL 0.2051 mL 0.4101 mL 1.0254 mL
100 mM 0.0328 mL 0.1641 mL 0.3281 mL 0.8203 mL
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Methyl clofenapate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl clofenapate21340-68-1Clofenapate methyl ester MCPPPARPeroxisome proliferator-activated receptorsliver cancerhepatocarcinogenesishypolipidemiaInhibitorinhibitorinhibit

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