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  6. Transcription Factor-Targeted Library
Transcription Factor-Targeted Library

Cat. No.: HY-L090

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1,403 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•   A unique collection of 1,403 small molecule compounds with validated transcription factor targets modulating properties.

•   Targeting more than 60 transcription factors, such as AP-1, ATF6, BCL6, NF-κB, etc.

•   A useful tool for the research of transcription factor-related regulation and diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 1,403 epigenetics related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 1,373 compounds supplied in 10 mM solution, 29 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

NF-κB (306)

STAT (120)

PPAR (119)

JNK (57)

ERK (42)

Wnt (37)

Akt (33)

COX (33)

YAP (29)

ROR (28)

Notch (25)

c-Myc (24)

JAK (21)

CDK (14)

HSP (13)

PI3K (13)

MMP (12)

AMPK (11)

HIV (11)

IKK (10)

AP-1 (9)

PARP (9)

EGFR (6)

mTOR (6)

BCL6 (5)

KLF (5)

MEK (5)

PIN1 (5)

Gli (4)

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  •  Concentration
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    Product Name:
    Transcription Factor-Targeted Library
    Cat. No.:
    HY-L090
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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