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  6. Mitochondrial Protection Compound Library
Mitochondrial Protection Compound Library

Cat. No.: HY-L144

Normal mitochondrial function is critical for maintaining cellular homeostasis because mitochondria produce ATP and are the major intracellular source of free radicals. Cellular dysfunctions induced by intracellular or extracellular insults converge on mitochondria and induce a sudden increase in permeability on the inner mitochondrial membrane, the so-called mitochondrial membrane permeability transition (MMPT). MMPT is caused by the opening of pores in the inner mitochondrial membrane, matrix swelling, and outer membrane rupture. The MMPT is an endpoint to initiate cell death because the pore opening together with the release of mitochondrial cytochrome c activates the apoptotic pathway of caspases.

The normal operation of mitochondrial function is important for maintaining normal cell death and treatment of mitochondrial diseases. MCE offers a unique collection of 627 compounds with identified and potential mitochondrial protective activity. MCE Mitochondrial Protection Compound Library is critical for drug discovery and development.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•    A unique collection of 627 mitochondrial protective compounds for high throughput screening (HTS) and high content screening (HCS).

•    A useful tool for the study of critical for drug discovery and development.

•    Target diverse, medicinally active and cell permeable.

•    Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•    More detailed compound information with structure, IC50, and other chemical & biological data.

•    High purity and quality validated by NMR and LC/MS.

Product Details

Formulation:

A collection of 627 mitochondrial protective compounds supplied as pre-dissolved Solutions or Solid
Solution: 612 compounds supplied in 10 mM solution, 15 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

Composition

mTOR (93)

PPAR (84)

PI3K (48)

Akt (37)

COX (29)

c-Myc (23)

ERK (14)

AMPK (11)

JNK (7)

MMP (6)

PARP (6)

HIV (5)

JAK (5)

HDAC (4)

HSV (4)

IKK (4)

ASCT (3)

PKA (3)

AP-1 (2)

CDK (2)

EGFR (2)

FKBP (2)

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Compound Customization
  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    Mitochondrial Protection Compound Library
    Cat. No.:
    HY-L144
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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