Methyl (E)-cinnamate (Synonyms: Methyl (E)-3-phenylpropenoate)

Cat. No.: HY-W067056: FAQs
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Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry.

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Methyl (E)-cinnamate Chemical Structure

CAS No. : 1754-62-7

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Other Forms of Methyl (E)-cinnamate:

Methyl cinnamate Get quote
Methyl (E)-cinnamate-d₅ Get quote
Methyl(E)-cinnamate-d₇ Get quote
Methyl (E)-cinnamate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Methyl (E)-cinnamate (0~30 μM; 24 hours; MC3T3-E1 cells) significantly increases the cleaved forms of poly (ADP-ribose) polymerase (PARP) and caspase-3, while it decreases the expression levels of Survivin and Bcl-2, and significantly increases TUNEL-positive and DAPI-stained cells^[1].
Methyl (E)-cinnamate (0~30 μM;7 days; MC3T3-E1 cells) suppresses the osteoblast differentiation^[1].
Methyl (E)-cinnamate (1~100 μM; 24 and 48 hours; MC3T3-E1 cells) decreases cell survival and induces morphological changes. EMC decreases MAPKs signaling and cell migration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MC3T3-E1 cells
Concentration:	0~30 μM
Incubation Time:	24 hours
Result:	Significantly increased the cleaved forms of poly (ADP-ribose) polymerase (PARP) and caspase-3, while it decreased the expression levels of Survivin and Bcl-2.

Apoptosis Analysis^[1]

Cell Line:	MC3T3-E1 cells
Concentration:	0~30 μM
Incubation Time:	24 hours
Result:	Significantly increased TUNEL-positive and DAPI-stained cells.

Cell Differentiation Assay^[1]

Cell Line:	MC3T3-E1 cells
Concentration:	0~30 μM
Incubation Time:	7 days
Result:	Suppressed the osteoblast differentiation.

Molecular Weight

162.19

Formula

C₁₀H₁₀O₂

CAS No.

1754-62-7

Appearance

<34°C Solid,>38°C Liquid

Color

Colorless to off-white

SMILES

O=C(OC)/C=C/C1=CC=CC=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Park KR, et al. A Phytochemical Constituent, (E)-Methyl-Cinnamate Isolated from Alpinia katsumadai Hayata Suppresses Cell Survival, Migration, and Differentiation in Pre-Osteoblasts. Int J Mol Sci. 2020;21(10):3700. Published 2020 May 24. [Content Brief]

Methyl (E)-cinnamate Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl (E)-cinnamate1754-62-7Methyl (E)-3-phenylpropenoateOthersphytochemicalAlpiniakatsumadaiHayatanaturalflavoranti-inflammatoryInhibitorinhibitorinhibit

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