2. PROTAC
  3. PROTAC Linkers
  4. Methyltetrazine-PEG4-maleimide

Methyltetrazine-PEG4-maleimide 

Cat. No.: HY-141278 Purity: 95.92%
SDS COA Handling Instructions

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Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Methyltetrazine-PEG4-maleimide Chemical Structure

Methyltetrazine-PEG4-maleimide Chemical Structure

CAS No. : 1802908-02-6

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Based on 1 publication(s) in Google Scholar

Methyltetrazine-PEG4-maleimide Related Antibodies

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Description

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methyltetrazine-PEG4-maleimide Related Antibodies
Molecular Weight

514.53

Formula

C24H30N6O7
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(NCCOCCOCCOCCOC1=CC=C(C2=NN=C(C)N=N2)C=C1)CCN3C(C=CC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 95.92%

SDS (393 KB)

COA (243 KB) HNMR (285 KB) RP-HPLC (226 KB) MS (69 KB)

Handling Instructions (2659 KB)
References
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Methyltetrazine-PEG4-maleimide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyltetrazine-PEG4-maleimide1802908-02-6PROTAC LinkersInhibitorinhibitorinhibit

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