MI-192

Cat. No.: HY-110264 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC₅₀s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities.

For research use only. We do not sell to patients.

MI-192 Chemical Structure

CAS No. : 1415340-63-4

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500 μg	USD 85	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	HL60 and Kasumi-1 cells
Concentration:	150 nM, 300 nM, 500 nM, 1 μM
Incubation Time:	72 h
Result:	Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.

In Vivo

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)^[2]
Dosage:	40 mg/kg
Administration:	i.p; once a day; for 3 days
Result:	Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.

Molecular Weight

383.44

Formula

C₂₄H₂₁N₃O₂

CAS No.

1415340-63-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=CC=C2C(CN1CC3=CC=C(C(NC4=C(C=CC=C4)N)=O)C=C3)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (13.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6080 mL	13.0399 mL	26.0797 mL
5 mM	0.5216 mL	2.6080 mL	5.2159 mL
10 mM	0.2608 mL	1.3040 mL	2.6080 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Marjorie Boissinot, et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36(10):1304-10. [Content Brief]

[2]. S V Demyanenko, et al. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):239-248. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6080 mL	13.0398 mL	26.0797 mL	65.1992 mL
	5 mM	0.5216 mL	2.6080 mL	5.2159 mL	13.0398 mL
	10 mM	0.2608 mL	1.3040 mL	2.6080 mL	6.5199 mL

MI-192 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-1921415340-63-4MI192MI 192HDACApoptosisHistone deacetylasesAnticanerneuroprotectiveHDAC2HDAC3apoptosisα-tubulinInhibitorinhibitorinhibit

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