1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel
  3. Mibefradil dihydrochloride hydrate

Mibefradil dihydrochloride hydrate  (Synonyms: Ro 40-5967 dihydrochloride hydrate)

Cat. No.: HY-15553B
Handling Instructions

Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels.

For research use only. We do not sell to patients.

Mibefradil dihydrochloride hydrate Chemical Structure

Mibefradil dihydrochloride hydrate Chemical Structure

CAS No. : 1049728-52-0

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Description

Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels[1].

IC50 & Target

Calcium channel[1]

In Vitro

Mibefradil inhibits reversibly the T- and L-type currents with IC50 values of 2.7 and 18.6 μM, respectively[2].
Mibefradil (20 µM) reduces the amplitude of excitatory junction potentials (by 37±10 %), slows the rate of repolarisation (by 44±16 %) and causes a significant membrane potential depolarisation (from -83±1 mV to -71±5 mV)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

586.57

Formula

C29H42Cl2FN3O4

CAS No.
SMILES

[H]O[H].O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Mibefradil dihydrochloride hydrate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mibefradil dihydrochloride hydrate
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HY-15553B
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