2. Anti-infection
  3. Antibiotic Bacterial
  4. Micronomicin sulfate

Micronomicin sulfate  (Synonyms: Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate)

Cat. No.: HY-108307 Purity: ≥98.0%
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Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml).

For research use only. We do not sell to patients.

Micronomicin sulfate Chemical Structure

Micronomicin sulfate Chemical Structure

CAS No. : 66803-19-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Micronomicin sulfate:

Micronomicin sulfate Related Antibodies

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Description

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic isolated from Micromonospora. Micronomicin sulfate is a broad-spectrum antibiotic close to the gentamicin-type antibiotics, exhibits a high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc (MIC=0.001-8.3 μg/ml)[1][2].

IC50 & Target

Aminoglycoside

 

In Vitro

Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Micronomicin sulfate Related Antibodies
In Vivo

Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD50 in mice of 93 mg/kg[1].
Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[3]
Dosage: 4, 10, 25, 63 mg/kg and 100 mg/kg
Administration: Intravenous injection; 30 days
Result: Led to death of rat at 100 mg/kg.
Formula

C20H41N5O7.xH2SO4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=S(O)(O)=O.O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@@H]2[C@H]([C@@H]([C@@H](N)C[C@H]2N)O[C@@]3([H])O[C@@H](CC[C@H]3N)CNC)O.[x]
Structure Classification
Initial Source

Micromonospora
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (256 KB) HNMR (195 KB) MS (68 KB)

Handling Instructions (2659 KB)
References
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Micronomicin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Micronomicin66803-19-8Gentamicin C2bAntibiotic XK-62-2SagamicinAntibioticBacterialStaphylococcus aureusBacillus subtilisEscherichia coliBaker 2F 14-BKand R5/W677bacterialinfectionInhibitorinhibitorinhibit

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