2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Midafotel

Midafotel  (Synonyms: SDZ-EAA 494)

Cat. No.: HY-107718 Purity: 99.00%
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Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects.

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Midafotel Chemical Structure

Midafotel Chemical Structure

CAS No. : 117414-74-1

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Based on 1 publication(s) in Google Scholar

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Description

Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects[1][2][3].

IC50 & Target[1]

NMDA Receptor

39 nM ()

In Vivo

Midafotel (15 mg/kg; i.p.) causes intense stereotyped behaviors in rats[2].
Midafotel (1.5, 4.5, 15 mg/kg; i.v.; initiated 15 min prior to MCA occlusion (followed by constant infusion at 1, 3 or 10 mg/kg/h)) produces dose-dependent reductions in the volumes of infarction; the dose of 4.5 mg/kg being the most effective in focal cerebral ischemia in the rat[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female Wistar rats[2]
Dosage: 15 mg/kg
Administration: I.p.
Result: Induced the typical PCP-like behavioral syndrome with ataxia, hyperlocomotion and stereotyped behaviors, i.e., head weaving, stereotyped sniffing, face washing and grooming, significantly increased extracellular levels of HVA and 5-HIAA in the striatum.
Molecular Weight

250.19

Formula

C8H15N2O5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H]1CN(CCN1)C/C=C/P(O)(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (99.92 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9970 mL 19.9848 mL 39.9696 mL
5 mM 0.7994 mL 3.9970 mL 7.9939 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.00%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9970 mL 19.9848 mL 39.9696 mL 99.9241 mL
5 mM 0.7994 mL 3.9970 mL 7.9939 mL 19.9848 mL
10 mM 0.3997 mL 1.9985 mL 3.9970 mL 9.9924 mL
15 mM 0.2665 mL 1.3323 mL 2.6646 mL 6.6616 mL
20 mM 0.1998 mL 0.9992 mL 1.9985 mL 4.9962 mL
25 mM 0.1599 mL 0.7994 mL 1.5988 mL 3.9970 mL
30 mM 0.1332 mL 0.6662 mL 1.3323 mL 3.3308 mL
40 mM 0.0999 mL 0.4996 mL 0.9992 mL 2.4981 mL
50 mM 0.0799 mL 0.3997 mL 0.7994 mL 1.9985 mL
60 mM 0.0666 mL 0.3331 mL 0.6662 mL 1.6654 mL
80 mM 0.0500 mL 0.2498 mL 0.4996 mL 1.2491 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Midafotel Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midafotel117414-74-1SDZ-EAA 494iGluRIonotropic glutamate receptorsstereotyped behaviorsneuroprotectiveInhibitorinhibitorinhibit

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