2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. (-)-5-HT2C agonist-3

(-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research.

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(-)-5-HT2C agonist-3 Chemical Structure

(-)-5-HT2C agonist-3 Chemical Structure

CAS No. : 2104810-16-2

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Other Forms of (-)-5-HT2C agonist-3:

(-)-5-HT2C agonist-3 Related Antibodies

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Description

(-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research[1].

IC50 & Target[1]

5-HT2A Receptor

72 nM (IC50)

5-HT2C Receptor

103 nM (IC50)

5-HT2B Receptor

570 nM (IC50)

Molecular Weight

351.84

Formula

C19H23ClFNO2
CAS No.
Appearance

Solid

SMILES

COC(C=CC=C1)=C1CNC[C@H]2[C@H](C3=C(C=CC(F)=C3)OC)C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (284.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8422 mL 14.2110 mL 28.4220 mL
5 mM 0.5684 mL 2.8422 mL 5.6844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8422 mL 14.2110 mL 28.4220 mL 71.0550 mL
5 mM 0.5684 mL 2.8422 mL 5.6844 mL 14.2110 mL
10 mM 0.2842 mL 1.4211 mL 2.8422 mL 7.1055 mL
15 mM 0.1895 mL 0.9474 mL 1.8948 mL 4.7370 mL
20 mM 0.1421 mL 0.7106 mL 1.4211 mL 3.5528 mL
25 mM 0.1137 mL 0.5684 mL 1.1369 mL 2.8422 mL
30 mM 0.0947 mL 0.4737 mL 0.9474 mL 2.3685 mL
40 mM 0.0711 mL 0.3553 mL 0.7106 mL 1.7764 mL
50 mM 0.0568 mL 0.2842 mL 0.5684 mL 1.4211 mL
60 mM 0.0474 mL 0.2369 mL 0.4737 mL 1.1843 mL
80 mM 0.0355 mL 0.1776 mL 0.3553 mL 0.8882 mL
100 mM 0.0284 mL 0.1421 mL 0.2842 mL 0.7106 mL
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(-)-5-HT2C agonist-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-5-HT2C agonist-32104810-16-25-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorGq signalingselectivityagonistspsychosisInhibitorinhibitorinhibit

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