2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. (-)-Bicuculline methochloride

(-)-Bicuculline methochloride  (Synonyms: l-Bicuculline methochloride)

Cat. No.: HY-100783A
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(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons.

For research use only. We do not sell to patients.

(-)-Bicuculline methochloride Chemical Structure

(-)-Bicuculline methochloride Chemical Structure

CAS No. : 53552-05-9

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Other Forms of (-)-Bicuculline methochloride:

(-)-Bicuculline methochloride Related Antibodies

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Description

(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1].

IC50 & Target

GABAA[1]
In Vivo

(-)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat L5-SNL model[2]
Dosage: 0.6 nmol/rat
Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result: Attenuated the antiallodynic effect of Neurotropin.
Molecular Weight

417.84

Formula

C21H20ClNO6
CAS No.
SMILES

C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Cl-]
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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(-)-Bicuculline methochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Bicuculline methochloride53552-05-9l-Bicuculline methochlorideGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBicucullinemethobromideGABA(A)afterhyperpolarizationsAHPsneuronsInhibitorinhibitorinhibit

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