(-)-Bicuculline methochloride (Synonyms: l-Bicuculline methochloride)

Cat. No.: HY-100783A: FAQs
Data Sheet Handling Instructions

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(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABA_A receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca²⁺-activated K⁺ channels in various types of neurons.

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(-)-Bicuculline methochloride Chemical Structure

CAS No. : 53552-05-9

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Description

IC₅₀ & Target

GABA_A^[1]

In Vivo

(-)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat L5-SNL model^[2]
Dosage:	0.6 nmol/rat
Administration:	Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:	Attenuated the antiallodynic effect of Neurotropin.

Molecular Weight

417.84

Formula

C₂₁H₂₀ClNO₆

CAS No.

53552-05-9

SMILES

C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Cl-]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70. [Content Brief]

[2]. Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9. [Content Brief]

(-)-Bicuculline methochloride Related Classifications

Neurological Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Bicuculline methochloride53552-05-9l-Bicuculline methochlorideGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorBicucullinemethobromideGABA(A)afterhyperpolarizationsAHPsneuronsInhibitorinhibitorinhibit

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