(-)-Halofantrine (Synonyms: (-)-SKF-102886 free base; (-)-WR-171669)

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(-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) is an inhibitor of the malignant malaria parasite (P. falciparum) and targets multidrug-resistant P. falciparum. The pharmacokinetic parameters of (-)-Halofantrine in rats vary depending on the route of administration, distinguishing it from other isomers.

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(-)-Halofantrine Chemical Structure

CAS No. : 66051-76-1

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Other Forms of (-)-Halofantrine:

Halofantrine Get quote

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Biological Activity
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Description

IC₅₀ & Target

P. falciparum^[1]

In Vivo

Pharmacokinetic data from rats of Halofantrine HCl under fasting conditions^[1]

Route	Dose (mg/kg)	Compound	AUC_0-∞ (mg·h/L)	Cl (mL/h/kg)	V_dss (L/kg)	V_dβ (L/kg)	t_1/2 (h)	C_max (ng/mL)	t_max (h)
i.v.	2; n=5	(-)-Halofantrine	5.02	199	3.22	4.64	16.8	/	/
		(+)-Halofantrine	9.06	113	2.38	3.13	20.8	/	/
		(±)-Halofantrine	14.1	143	3.53	3.60	18.0	/	/
p.o.	14; n=5	(-)-Halofantrine	5.49	/	/	/	16.6	556	2.20
		(+)-Halofantrine	16.3	/	/	/	16.5	917	4.20
		(±)-Halofantrine	22.5	/	/	/	16.4	1420	3.60

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

500.42

Formula

C₂₆H₃₀Cl₂F₃NO

CAS No.

66051-76-1

SMILES

OC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31.[Rotation (-)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brocks DR, et al. Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons. Biopharm Drug Dispos. 1999 Apr;20(3):165-9. [Content Brief]

(-)-Halofantrine Related Classifications

Infection

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Halofantrine66051-76-1(-)-SKF-102886 (-)-WR-171669ParasiteInhibitorinhibitorinhibit

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