2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Antifolate
  4. Mirvetuximab soravtansine (solution)

Mirvetuximab soravtansine (solution)  (Synonyms: IMGN853 (solution))

Cat. No.: HY-132258A
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Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage.

For research use only. We do not sell to patients.

Mirvetuximab soravtansine (solution) Chemical Structure

Mirvetuximab soravtansine (solution) Chemical Structure

CAS No. : 1453084-37-1

Size Price Stock Quantity
Solvent
1 mg（10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5） USD 950 In-stock
Solvent
5 mg（10.246 mg/mL * 488 μL in 10mM Histidine pH=5.5） USD 3050 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage[1].

In Vitro

Mirvetuximab soravtansine (IMGN853; 8 nM; 6 h; IGROV-1 cells) combined with Carboplatin (HY-17393) promotes synergistic growth inhibitory effects and cell cycle perturbations in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mirvetuximab soravtansine (solution) Related Antibodies
In Vivo

Mirvetuximab soravtansine (IMGN853; 5 mg/kg; i.v.; female severe combined immunodeficient (SCID) mice with patient-derived xenografts) potentiates the antitumor activity of Carboplatin in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

150000 (average)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Mirvetuximab soravtansine (solution)]
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Purity & Documentation
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Mirvetuximab soravtansine (solution) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mirvetuximab soravtansine (solution)1453084-37-1IMGN853 (solution)Antibody-Drug Conjugates (ADCs)AntifolateAntibody-Drug ConjugatesInhibitorinhibitorinhibit

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