MitoB-d₁₅ bromide

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MitoB-d₁₅ (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals.

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MitoB-d<sub>15</sub> bromide Chemical Structure

MitoB-d₁₅ bromide Chemical Structure

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Description	MitoB-d₁₅ (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals^[1]^[2].
Molecular Weight	492.23
Formula	C₂₅H₈D₁₅BBrO₂P
Unlabeled CAS	1247025-84-8
SMILES	OB(C1=CC=CC(C[P+](C2=C(C([2H])=C(C([2H])=C2[2H])[2H])[2H])(C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])C4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=C1)O.[Br-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Salin K, et al. Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Sci Rep. 2017 Jan 24;7:41228. [Content Brief] [3]. Cochemé HM, et al. Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nat Protoc. 2012 Apr 19;7(5):946-58. [Content Brief]