2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Mitobronitol

Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia.

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Mitobronitol Chemical Structure

Mitobronitol Chemical Structure

CAS No. : 488-41-5

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Based on 1 publication(s) in Google Scholar

Mitobronitol Related Antibodies

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Description

Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia[1][2].

In Vivo

Mitobronitol (850 mg/kg; i.p.; single dose) improves spleen cells to mitogens and enhances thymus regeneration in mice model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (8-10 weeks old)[2]
Dosage: 850 mg/kg; 1500 mg/kg (suspended in 5% Tween 80 in saline, 0.5 mL)
Administration: Intraperitoneal injection; single dose
Result: Showed effect on the in vitro proliferative response of spleen cells to mitogens at 850 mg/kg.
Enhanced thymus regeneration and was earlier than control, with the starting resititution time-course of 2 weeks and subtotal resititution time course of 3 weeks under 1500 mg/kg dose.
Clinical Trial
Molecular Weight

307.97

Formula

C6H12Br2O4
CAS No.
SMILES

O[C@@H]([C@H]([C@@H]([C@@H](CBr)O)O)O)CBr
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Purity & Documentation
References
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Mitobronitol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitobronitol488-41-5Myelobromol DBMDNA Alkylator/Crosslinkeranticancerbrominated sugar alcohol derivativealkylationantimetabolitemannitolmyelosuppressionInhibitorinhibitorinhibit

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