Mitochondrial respiration-IN-3 

Mitochondrial respiration-IN-3 is the fluorine derivative of Dalfopristin (HY-A0241). Mitochondrial respiration-IN-3 has cell membrane-permeable. Mitochondrial respiration-IN-3 can inhibit mitochondrial translation of glioblastoma stem cells. Mitochondrial respiration-IN-3 can be used in research of cancer^[1].

Mitochondrial respiration-IN-3 ((16R)-1e; 48 h; COMI cells) inhibits cell growth with a GI₅₀ value of 6.73 μM^[1].
Mitochondrial respiration-IN-3 (100 μM; 3 h; COMI cells) has good cell membrane-permeable and increases permeability compared to Dalfopristin^[1].
Mitochondrial respiration-IN-3 (0-5 μM; 48 h; COMI cells) inhibits mitochondrial translation in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

694.85

C₃₄H₅₁FN₄O₈S

O=S([C@H]1[C@@]2(C(O[C@H](C(C)C)[C@H](C)/C=C/C(NC/C=C/C(C)=C/[C@@H](O)C[C@@H](F)CC3=NC(C(N2CC1)=O)=CO3)=O)=O)[H])(CCN(CC)CC)=O

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• [1]. Sighel D, et, al. Streptogramin A derivatives as mitochondrial translation inhibitors to suppress glioblastoma stem cell growth. Eur J Med Chem. 2023 Jan 15;246:114979.  [Content Brief]