2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. MitTx-alpha

MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels.

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MitTx-alpha Chemical Structure

MitTx-alpha Chemical Structure

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MitTx-alpha Related Antibodies

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Description

MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels[1].

Molecular Weight

7103.94

Formula

C317H440N86O89S7
Sequence

{Pyr}-Ile-Arg-Pro-Ala-Phe-Cys-Tyr-Glu-Asp-Pro-Pro-Phe-Phe-Gln-Lys-Cys-Gly-Ala-Phe-Val-Asp-Ser-Tyr-Tyr-Phe-Asn-Arg-Ser-Arg-Ile-Thr-Cys-Val-His-Phe-Phe-Tyr-Gly-Gln-Cys-Asp-Val-Asn-Gln-Asn-His-Phe-Thr-Thr-Met-Ser-Glu-Cys-Asn-Arg-Val-Cys-His-Gly (Disulfide bridge: Cys7-Cys54; Cys17-Cys41; Cys33-Cys58)
Sequence Shortening

{Pyr}-IRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG (Disulfide bridge: Cys7-Cys54; Cys17-Cys41; Cys33-Cys58)
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3C(C)C)=O)=O)=O)NC4=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%10=CNC=N%10)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@H]4CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%12=O)C(NCC(N[C@@H](C)C(N[C@@H](CC%13=CC=CC=C%13)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC%14=CC=C(C=C%14)O)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CC%16=CC=CC=C%16)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC%17=CNC=N%17)C(NCC(O)=O)=O)=O)NC3=O)C(N[C@@H](C(C)C)C(N[C@@H](CC%18=CNC=N%18)C(N[C@@H](CC%19=CC=CC=C%19)C(N[C@@H](CC%20=CC=CC=C%20)C(N[C@@H](CC%21=CC=C(C=C%21)O)C(NCC(N[C@H]%12CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC([C@@H]%22CCC(N%22)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MitTx-alpha Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MitTx-alphaSodium ChannelNa channelsNa+ channelsMitTxacid-sensing ion channelsASICsASIC1,neutral pHASIC2aInhibitorinhibitorinhibit

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