MK-0941 free base

Cat. No.: HY-19843A: FAQs
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MK-0941 free base is an orally active glucokinase activator, with EC₅₀s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

For research use only. We do not sell to patients.

MK-0941 free base Chemical Structure

CAS No. : 752240-01-0

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Other Forms of MK-0941 free base:

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Description

IC₅₀ & Target

Glucokinase^[1]^[2].

In Vivo

MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male db/db and db/+ (lean) mice (9-10 weeks of age, weighing 43-45 g) ^[1].
Dosage:	3 or 10 mg/kg.
Administration:	Oral gavage, single dose.
Result:	Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.

Clinical Trial

Molecular Weight

460.50

Formula

C₂₁H₂₄N₄O₆S

CAS No.

752240-01-0

SMILES

O=C(NC1=NN(C)C=C1)C2=CC(O[C@@H](C)CO)=CC(OC3=CC=C(S(=O)(CC)=O)N=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Eiki J, et al. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Mol Pharmacol. 2011 Dec;80(6):1156-65. [Content Brief]

[2]. Meininger GE, et al. Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes. Diabetes Care. 2011 Dec;34(12):2560-6. [Content Brief]

MK-0941 free base Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0941752240-01-0MK0941MK 0941GlucokinaseHexokinase IVHexokinase DInhibitorinhibitorinhibit

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