2. Autophagy
  3. LRRK2
  4. MK-1468

MK-1468 is a high selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 0.8 nM. MK-1468 can be used in study Parkinson’s disease.

For research use only. We do not sell to patients.

MK-1468 Chemical Structure

MK-1468 Chemical Structure

CAS No. : 2769107-89-1

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Based on 1 publication(s) in Google Scholar

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Description

MK-1468 is a high selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 0.8 nM. MK-1468 can be used in study Parkinson’s disease[1].

Molecular Weight

501.02

Formula

C26H33ClN4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C(N1CCN([C@]2([C@H](COC2)O)C)CC1)=C3)=CC(C=N4)=C3C=C4NC([C@@H]5C6(CCOCC6)C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (199.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9959 mL 9.9796 mL 19.9593 mL
5 mM 0.3992 mL 1.9959 mL 3.9919 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.69%

SDS (251 KB)

COA (248 KB) HNMR (283 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9959 mL 9.9796 mL 19.9593 mL 49.8982 mL
5 mM 0.3992 mL 1.9959 mL 3.9919 mL 9.9796 mL
10 mM 0.1996 mL 0.9980 mL 1.9959 mL 4.9898 mL
15 mM 0.1331 mL 0.6653 mL 1.3306 mL 3.3265 mL
20 mM 0.0998 mL 0.4990 mL 0.9980 mL 2.4949 mL
25 mM 0.0798 mL 0.3992 mL 0.7984 mL 1.9959 mL
30 mM 0.0665 mL 0.3327 mL 0.6653 mL 1.6633 mL
40 mM 0.0499 mL 0.2495 mL 0.4990 mL 1.2475 mL
50 mM 0.0399 mL 0.1996 mL 0.3992 mL 0.9980 mL
60 mM 0.0333 mL 0.1663 mL 0.3327 mL 0.8316 mL
80 mM 0.0249 mL 0.1247 mL 0.2495 mL 0.6237 mL
100 mM 0.0200 mL 0.0998 mL 0.1996 mL 0.4990 mL
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MK-1468 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-14682769107-89-1MK1468MK 1468LRRK2Leucine-rich repeat kinase 2LRRK2 InhibitorBrain-PenetrantParkinson’s DiseaseInhibitorinhibitorinhibit

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