MK-4688

Cat. No.: HY-139846: FAQs
Data Sheet Handling Instructions

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MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.

For research use only. We do not sell to patients.

MK-4688 Chemical Structure

CAS No. : 1616428-79-5

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Description	MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.
Molecular Weight	550.05
Formula	C₂₈H₃₂ClN₇O₃
CAS No.	1616428-79-5
SMILES	C[C@@H](CC1)CC[C@H]1CN(C(N2CCO[C@H]3[C@H]2CCC3)=N4)C5=C4C=C(C(N6)=NOC6=O)N=C5C7=CC(Cl)=CN=C7
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Reutershan MH, et al. Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64(21):16213-16241. [Content Brief]

MK-4688 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-46881616428-79-5MK4688MK 4688OthersInhibitorinhibitorinhibit

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MK-4688

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