2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. MK-8825

MK-8825 is an orally active, potent and selective CGRP receptor antagonist, which shows concentration-dependent inhibition of Capsaicin (HY-10448)-evoked dermal blood flow with an EC50 of about 7.4 μM. MK-8825 inhibits CGRP-induced spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines in a mouse model of acute orofacial masseteric muscle pain. MK-8825 is promising for research of acute migraine.

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MK-8825 Chemical Structure

MK-8825 Chemical Structure

CAS No. : 1380887-60-4

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Description

MK-8825 is an orally active, potent and selective CGRP receptor antagonist, which shows concentration-dependent inhibition of Capsaicin (HY-10448)-evoked dermal blood flow with an EC50 of about 7.4 μM. MK-8825 inhibits CGRP-induced spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines in a mouse model of acute orofacial masseteric muscle pain. MK-8825 is promising for research of acute migraine[1][2].

Molecular Weight

572.61

Formula

C31H30F2N6O3
CAS No.
SMILES

O=C1[C@]2(CC3=CC(NC(CN4[C@@](CNC5(CCCC5)C4=O)(C6=CC(F)=CC(F)=C6)C)=O)=CN=C3C2)C7=CC=CN=C7N1
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Purity & Documentation
References
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MK-8825 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-88251380887-60-4MK8825MK 8825CGRP ReceptorCalcitonin gene-related peptide receptororally activeCGRP receptor antagonistcapsaicin-evoked dermal blood flowneuronal activationpro-inflammatory cytokinesacute migraineInhibitorinhibitorinhibit

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