ML338 

ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC₉₀ and IC₉₉ values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy^[1].

IC90: 1 μM (non-replicating Mycobacterium tuberculosis bacilli)
IC99: 4 μM (non-replicating Mycobacterium tuberculosis bacilli)

ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC₉₀ of 1 μM. Additionally, ML338 have an IC₉₉ against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs^[1].
ML338  (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration^[1].
ML338 is against the non-replicating M. tuberculosis with IC₉₀ and IC₉₉ velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC₉₀ and IC₉₉ velues of 62 μM and 62 μM, respectively by CFU^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

369.83

C₁₇H₁₂ClN₅OS

1630160-25-6

ClC1=CC=C(C2=NN=C(SCC3=CN(C4=CC=CC=C4)N=N3)O2)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Partha P. Nag,et al. Elucidation of the Physiology of Non-Replicating, Drug Tolerant Mycobacterium tuberculosis With the Aid of the Small Molecule Probe ML338. Review  [Content Brief]