2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. ML353

ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

ML353 Chemical Structure

ML353 Chemical Structure

CAS No. : 2990506-75-5

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Based on 1 publication(s) in Google Scholar

ML353 Related Antibodies

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Description

ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker[1]. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

mGlu5

18.2 nM (Ki)

In Vitro

ML353 is a fully soluble compound with a solubility of 16.9 µM or 6.0 µg/mL in PBS (PH=7.4)[1].
ML353 has excellent stability in PBS buffer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML353 Related Antibodies
Molecular Weight

306.33

Formula

C19H15FN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC=C(C#CC2=CC(F)=CC=C2)C=C1)N(C3)CC4C3C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (163.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2645 mL 16.3223 mL 32.6445 mL
5 mM 0.6529 mL 3.2645 mL 6.5289 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2645 mL 16.3223 mL 32.6445 mL 81.6113 mL
5 mM 0.6529 mL 3.2645 mL 6.5289 mL 16.3223 mL
10 mM 0.3264 mL 1.6322 mL 3.2645 mL 8.1611 mL
15 mM 0.2176 mL 1.0882 mL 2.1763 mL 5.4408 mL
20 mM 0.1632 mL 0.8161 mL 1.6322 mL 4.0806 mL
25 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2645 mL
30 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7204 mL
40 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
50 mM 0.0653 mL 0.3264 mL 0.6529 mL 1.6322 mL
60 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3602 mL
80 mM 0.0408 mL 0.2040 mL 0.4081 mL 1.0201 mL
100 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8161 mL
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ML353 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML3532990506-75-5ML 353ML-353mGluRMetabotropic glutamate receptorsSAMSolubilityStabilityInhibitorinhibitorinhibit

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