2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR1 antagonist 10

CCR1 antagonist 10 (example 1) is a potent and orally active CCR1 antagonist. CCR1 antagonist 10 inhibits 125I-MIP-1α binding to THP-1 cell membranes with an Ki value of 2.3 nM.

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CCR1 antagonist 10 Chemical Structure

CCR1 antagonist 10 Chemical Structure

CAS No. : 1010731-97-1

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CCR1 antagonist 10 Related Antibodies

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Description

CCR1 antagonist 10 (example 1) is a potent and orally active CCR1 antagonist. CCR1 antagonist 10 inhibits 125I-MIP-1α binding to THP-1 cell membranes with an Ki value of 2.3 nM[1].

IC50 & Target[1]

CCR1

 

Molecular Weight

519.03

Formula

C30H31ClN2O4
CAS No.
SMILES

O=C(C1=CC=C(OCC2=NC=CC=C2/C3=C\CCN4CC(C)(C)[C@@](O)(C5=CC=C(Cl)C=C5)CC4)C3=C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCR1 antagonist 10 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR1 antagonist 101010731-97-1CCRCC chemokine receptorInhibitorinhibitorinhibit

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