2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. MMG-0358

MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4.

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MMG-0358 Chemical Structure

MMG-0358 Chemical Structure

CAS No. : 1378976-02-3

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Based on 1 publication(s) in Google Scholar

MMG-0358 Related Antibodies

Top Publications Citing Use of Products

View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

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IDO1 IDO2 IDO

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Description

MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4[1].

IC50 & Target

IDO1

330 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
0.082 μM
Compound: MMG-0358
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
[PMID: 31525930]
P815 IC50
> 100 μM
Compound: 35, MMG-0358
Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
[PMID: 22616902]
P815 IC50
0.002 μM
Compound: 35, MMG-0358
Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
[PMID: 22616902]
Molecular Weight

195.61

Formula

C8H6ClN3O
CAS No.
SMILES

ClC1=CC(C2=CN=NN2)=C(O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MMG-0358 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMG-03581378976-02-3MMG0358MMG 0358Indoleamine 2,3-Dioxygenase (IDO)Inhibitorinhibitorinhibit

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