MMP-9-IN-3 

MMP-9-IN-3 is a MMP-9 inhibitor (IC₅₀: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC₅₀: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers^[1].

MMP-9-IN-3 (compound 28, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells^[1].
MMP-9-IN-3 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively^[1].
MMP-9-IN-3 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively^[1].
MMP-9-IN-3 (5.7 nM, 24 h) inhibits cell migration in HepG-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

479.53

C₂₉H₂₅N₃O₄

2581824-48-6

O=C(C(N(C(CC1=CC=CC=C1)=O)CC2=CC=CC=C2)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mohammed Salah Ayoup, et al. Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. Eur J Med Chem. 2020 Jan 15;186:111875.  [Content Brief]