2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Apoptosis
  3. MMP Akt Apoptosis
  4. MMP-9-IN-3

MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers.

For research use only. We do not sell to patients.

MMP-9-IN-3 Chemical Structure

MMP-9-IN-3 Chemical Structure

CAS No. : 2581824-48-6

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MMP-9-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All MMP Isoform Specific Products:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

View All Akt Isoform Specific Products:

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Akt Akt1 Akt2 Akt3

  • Biological Activity

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Description

MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers[1].

IC50 & Target[1]

MMP-9

5.56 nM (IC50)

MMP-1

447 nM (IC50)

MMP-2

221 nM (IC50)

MMP13

295 nM (IC50)

AKT

2.11 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
5.7 nM
Compound: 28
Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
MCF7 IC50
6.6 nM
Compound: 28
Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
NFS-60 IC50
5.8 nM
Compound: 28
Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
WI-38 IC50
314 nM
Compound: 28
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
[PMID: 31740054]
In Vitro

MMP-9-IN-3 (compound 28, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-3 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively[1].
MMP-9-IN-3 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively[1].
MMP-9-IN-3 (5.7 nM, 24 h) inhibits cell migration in HepG-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MMP-9-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells
Concentration: 0-1 μM approximately
Incubation Time: 72 h
Result: Showed cytotoxicity with IC50: 314 nM (Wi-38), 6.6 nM (MCF-7), 5.8 nM (NFS-60), 5.7 nM (HepG-2).

Cell Migration Assay [1]

Cell Line: HepG-2
Concentration: 5.7 nM
Incubation Time: 24 h
Result: Inhibited cell migration by 71.25%.
Molecular Weight

479.53

Formula

C29H25N3O4
CAS No.
SMILES

O=C(C(N(C(CC1=CC=CC=C1)=O)CC2=CC=CC=C2)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MMP-9-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-9-IN-32581824-48-6MMPAktApoptosisMatrix metalloproteinasesPKBProtein kinase BCancertumorWi-38MCF-7NFS-60HepG-2cytotoxicitymigrationInhibitorinhibitorinhibit

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