MMT5-14

Cat. No.: HY-151265: FAQs
Data Sheet Handling Instructions

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MMT5-14 is a remdesivir analogue with a higher antiviral activity in four variants of SARS-CoV-2 than Remdesivir (HY-104077). MMT5-14 inhibits SARS-CoV-2, α, β, γ and δ variants with EC₅₀s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively. MMT5-14 can be used for the research of COVID-19.

For research use only. We do not sell to patients.

MMT5-14 Chemical Structure

CAS No. : 2719679-31-7

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Description

In Vitro

MMT5-14 (10 μM; 0-12 h) increases epithelial cell uptake^[1].
MMT5-14 (5 μM; 2 d) shows a better in vitro antiviral activity than remdesivir^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Vero-E6 cell line
Concentration:	5 μM
Incubation Time:	2 days
Result:	Inhibited SARS-CoV-2, alpha, beta, gamma and delta variants with EC₅₀s of 0.4, 2.5, 15.9, 1.7 and 5.6 μM, respectively.

In Vivo

MMT5-14 (10 mg/kg; i.v. once) shows a higher stability than remdesivir in microsomes, and shows higher concentrations of prodrugs and active metabolites (NTP) in blood and lungs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Catheterized female hamsters^[1]
Dosage:	10 mg/kg
Administration:	Intravenous injection; 10 mg/kg once
Result:	Showed higher intact prodrugs concentration than remdesivir in lungs after 4 hours injection, increased tissue exposure in most of the tissues and showed 5- to 10-fold higher tissue selectivity in lungs compared to remdesivir.

Molecular Weight

766.86

Formula

C₃₉H₅₅N₆O₈P

CAS No.

2719679-31-7

SMILES

C[C@@H](C(OCCCCCCCC/C=C\C/C=C\CCCCC)=O)NP(OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu H, et al. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity. J Med Chem. 2022 Sep 7. [Content Brief]

MMT5-14 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMT5-142719679-31-7SARS-CoVSARS coronavirusepithelialremdesivirvariantsantiviralCOVID-19hamsterInhibitorinhibitorinhibit

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