MNK1/2-IN-8

Cat. No.: HY-158438: FAQs
Data Sheet Handling Instructions

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MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC₅₀ values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest.

For research use only. We do not sell to patients.

MNK1/2-IN-8 Chemical Structure

CAS No. : 2430793-35-2

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MNK1 MNK2 MNK

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

MNK1

0.8 nM (IC₅₀)

MNK2

1.5 nM (IC₅₀)

In Vitro

MNK1/2-IN-8 (compound 15b) inhibits cell growth with the GI₅₀ of 7.68, 1.59, 3.60 and 2.39 μM against HCT-116,MOLM-13, K562 and HL-60, respectively^[1].
MNK1/2-IN-8 (compound 15b) (1,2,and 4μM, 24 h) induces cell cycle arrest in MOLM-13 and K562 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MNK1/2-IN-8 (compound 15b) inhibits tumor growth in xenograft model of lung cancer LL/2 cells in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

436.51

Formula

C₂₆H₂₄N₆O

CAS No.

2430793-35-2

SMILES

O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499. [Content Brief]

MNK1/2-IN-8 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK1/2-IN-82430793-35-2MNKMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseMOLM-13K562cell cycleLL/2 syngeneic modelHCT-116HL-60Inhibitorinhibitorinhibit

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