MOG(35-55) amide, mouse, rat

Name: MOG(35-55) amide, mouse, rat
Brand: MedChemExpress
SKU: HY-P3719
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3719 Purity: 99.10%: FAQs
Data Sheet SDS COA Handling Instructions

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MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide. MOG peptide (35-55) is specific to expanded CD4⁺ T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model.

For research use only. We do not sell to patients.

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MOG(35-55) amide, mouse, rat Chemical Structure

CAS No. : 2022956-48-3

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5 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

In Vitro

The expanded CD4⁺ T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8⁺ T cells were non-responsive to myelin peptides or proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MOG(35-55) amide, mouse, rat (3 mg/mL for 0.1 mL; s.c.; single dose) results active induction of experimental autoimmune encephalomyelitis (EAE) in mice^[2].
MOG(35-55) amide, mouse, rat (200 μg; s.c.; single dose) induces a increasing concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	129S1/SvImJ, C57BL/6 and C57BL/6 X SJL hybrid^[2]
Dosage:	3 mg/mL, 0.1 mL per mice; accompanied with CFA and 4 mg/mL Mycobacterium tuberculosis
Administration:	Subcutaneous injection; single dose
Result:	Showed the expected signs of experimental autoimmune encephalomyelitis (EAE), which started with tail loss of tonus and continued in an ascending fashion in mice immunized with MOG35-55.

Animal Model:	C57BL/6 mice (8-12 weeks)^[3]
Dosage:	200 μg
Administration:	Subcutaneous injection; single dose; analyzed at pre-onset (day 7 post immunization), onset (day 9-13 post immunization) and peak (day 17-19 post immunization)
Result:	Increased eosinophil abundance in the spinal cord increases in the course of EAE.

Molecular Weight

2580.97

Formula

C₁₁₈H₁₇₈N₃₆O₂₈S

CAS No.

2022956-48-3

Appearance

Solid

Color

White to light yellow

Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-NH2

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (38.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3875 mL	1.9373 mL	3.8745 mL
5 mM	0.0775 mL	0.3875 mL	0.7749 mL
10 mM	0.0387 mL	0.1937 mL	0.3875 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (243 KB) LCMS (89 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Saligrama N, et al. Opposing T cell responses in experimental autoimmune encephalomyelitis. Nature. 2019 Aug;572(7770):481-487. [Content Brief]

[2]. Giralt M, et al. Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse. Methods Mol Biol. 2018;1791:227-232. [Content Brief]

[3]. Ruppova K, et al. Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice. Immunol Lett. 2021 Nov;239:72-76. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3875 mL	1.9373 mL	3.8745 mL	9.6863 mL
	5 mM	0.0775 mL	0.3875 mL	0.7749 mL	1.9373 mL
	10 mM	0.0387 mL	0.1937 mL	0.3875 mL	0.9686 mL
	15 mM	0.0258 mL	0.1292 mL	0.2583 mL	0.6458 mL
	20 mM	0.0194 mL	0.0969 mL	0.1937 mL	0.4843 mL
	25 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.3875 mL
	30 mM	0.0129 mL	0.0646 mL	0.1292 mL	0.3229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.