Monomethyl auristatin E intermediate-3

Cat. No.: HY-43146: FAQs
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Monomethyl auristatin E intermediate-3 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Monomethyl auristatin E intermediate-3 Chemical Structure

Size	Price	Stock	Quantity
50 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Description	Monomethyl auristatin E intermediate-3 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)^[1].
Molecular Weight	265.30
Formula	C₁₄H₁₉NO₄
Appearance	Oil
Color	Colorless to light yellow
SMILES	CCC(C)C(C(O)=O)NC(OCC1=CC=CC=C1)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. [Content Brief]

Monomethyl auristatin E intermediate-3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Monomethyl auristatin E intermediate-3Monomethyl auristatin E intermediate3Monomethyl auristatin E intermediate 3OthersInhibitorinhibitorinhibit

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Monomethyl auristatin E intermediate-3

Monomethyl auristatin E intermediate-3 Related Antibodies

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