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  3. Monomethyl lithospermate

Monomethyl lithospermate  (Synonyms: Lithospermic acid monomethyl ester)

Cat. No.: HY-N8931
Handling Instructions

Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS).

For research use only. We do not sell to patients.

Monomethyl lithospermate Chemical Structure

Monomethyl lithospermate Chemical Structure

CAS No. : 933054-33-2

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Description

Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS)[1].

In Vitro

Monomethyl lithospermate (5, 10, and 20 μM; 12 h) increases cell viability of SHSY-5Y cells treated by oxygen and glucose deprivation/Reoxygenation (OGD/R)[1].
Monomethyl lithospermate (20 μM; 12 h) alleviates cell damage, mitochondrial membrane potential loss and apoptosis of SHSY-5Y cells after oxygen and glucose deprivation/reoxygenation[1].
Monomethyl lithospermate (5, 10, and 20 μM; 12 h) reduces ROS and intracellular oxidative stress in SHSY-5Y cells[1].
Monomethyl lithospermate (20 μM; 12 h) activates PI3K/AKT in SHSY-5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence[1]

Cell Line: SHSY-5Y cells
Concentration: 5, 10, and 20 μM
Incubation Time: 12 hours
Result: Inhibited the mitochondrial membrane potential (MMOP) collapse and apoptosis of SHSY-5Y cells induced by oxygen and glucose deprivation/Reoxygenation (OGD/R) treatment.
In Vivo

Monomethyl lithospermate (72.4 μM/kg; p.o.; once daily for 14 d) improves the neurological function of middle artery occlusion (MCAO) rats 24 h after ischemia reperfusion (IR), and reduces the size of cerebral infarction; also reduces the level of oxidative stress and inhibit neuronal apoptosis in MCAO rats[1].
Monomethyl lithospermate can reduce the oxidative stress level and inhibit neuronal apoptosis in MCAO rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

552.48

Formula

C28H24O12

CAS No.
SMILES

O=C(/C=C/C1=C2C(O[C@@H]([C@H]2C(OC)=O)C3=CC(O)=C(O)C=C3)=C(O)C=C1)O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Monomethyl lithospermate
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