mPEG-amine (MW 5000)  (Synonyms: mPEG-NH2 (MW 5000))

mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies^[1][2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5000(Average)

(C₂H₄O)_nC₃H₉NO

80506-64-5

Solid

White to off-white

COCCOCCN.[n]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Patrick MJ, et al. Enhanced aqueous solubility of long wavelength voltage-sensitive dyes by covalent attachment of polyethylene glycol. Org Biomol Chem. 2007 Oct 21;5(20):3347-53.  [Content Brief]

  [2]. Suzuki K, et al. Spatial confinement of active microtubule networks induces large-scale rotational cytoplasmic flow. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2922-2927.  [Content Brief]