2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase PGE synthase
  4. mPGES-1/5-LOX-IN-1

mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact.

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mPGES-1/5-LOX-IN-1 Chemical Structure

mPGES-1/5-LOX-IN-1 Chemical Structure

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mPGES-1/5-LOX-IN-1 Related Antibodies

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Description

mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact[1].

IC50 & Target[1]

5-LOX

1.89 μM (IC50)

mPGES-1

0.92 μM (IC50)

In Vivo

mPGES-1/5-LOX-IN-1 (compound 3j) (10 mg/kg; p.o.) shows anti-inflammatory effects and reduces the levels of pro-inflammatory cytokines (PGE2, TNF-α, and IL-6) with gastrointestinal safety profiles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rat[1]
Dosage: 10 mg/kg
Administration: P.o.
Result: Showed anti-inflammatory impact and inhibited serum concentrations of PGE2, TNF-α and IL-6, did not generate ulceration in the isolated rat stomach.
Molecular Weight

446.48

Formula

C20H22N4O6S
SMILES

O=C(C1=C(C)NC(NC1C2=CC=C(OC)C(OC)=C2)=O)NC3=CC=C(S(=O)(N)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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mPGES-1/5-LOX-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mPGES-1/5-LOX-IN-1LipoxygenasePGE synthaseLOXProstaglandin E synthasePGE2TNF-αIL-6orally activeanti-inflammatoryInhibitorinhibitorinhibit

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