2. Cytoskeleton
  3. Myosin
  4. MPH-220

MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness.

For research use only. We do not sell to patients.

MPH-220 Chemical Structure

MPH-220 Chemical Structure

CAS No. : 2649776-79-2

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1 mg USD 204 In-stock
5 mg USD 510 In-stock
10 mg USD 810 In-stock
25 mg USD 1600 In-stock
50 mg USD 2600 In-stock
100 mg USD 4200 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of MPH-220:

MPH-220 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].

In Vitro

MPH-220 (0-50 µM) inhibits Actin-activated ATPase activity in human muscle myosin samples[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPH-220 Related Antibodies
In Vivo

MPH-220 (25-30 mg/kg, i.p. or oral gavage) reduces skeletal muscle force without cardiovascular effects in anesthetized rats[1].
MPH-220 (15 mg/kg, oral administration) improves gait functions in rats with brain injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized rats[1]
Dosage: 25-30 mg/kg
Administration: Intraperitoneal injection (i.p.) or oral gavage
Result: Reduced skeletal muscle force.
Observed MPH-220 distribution in rat tissues in a time-dependent manner and a dose-dependent, few-fold accumulation in skeletal muscle.
Molecular Weight

383.46

Formula

C20H21N3O3S
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O[C@@]12C(N(C3=CC=C(N4CCOCC4)C=C3)CC2)=NC5=C(C=C(S5)C)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6078 mL 13.0392 mL 26.0783 mL
5 mM 0.5216 mL 2.6078 mL 5.2157 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6078 mL 13.0392 mL 26.0783 mL 65.1958 mL
5 mM 0.5216 mL 2.6078 mL 5.2157 mL 13.0392 mL
10 mM 0.2608 mL 1.3039 mL 2.6078 mL 6.5196 mL
15 mM 0.1739 mL 0.8693 mL 1.7386 mL 4.3464 mL
20 mM 0.1304 mL 0.6520 mL 1.3039 mL 3.2598 mL
25 mM 0.1043 mL 0.5216 mL 1.0431 mL 2.6078 mL
30 mM 0.0869 mL 0.4346 mL 0.8693 mL 2.1732 mL
40 mM 0.0652 mL 0.3260 mL 0.6520 mL 1.6299 mL
50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.3039 mL
60 mM 0.0435 mL 0.2173 mL 0.4346 mL 1.0866 mL
80 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8149 mL
100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6520 mL
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MPH-220 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPH-2202649776-79-2MPH220MPH 220Myosinmuscle myosinanti-spasticmuscle relaxationspasticitystiffnessATPaseActinInhibitorinhibitorinhibit

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