MPI-0441138

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MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death.

For research use only. We do not sell to patients.

MPI-0441138 Chemical Structure

CAS No. : 827030-33-1

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Description

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	1.2 nM Compound: 8	Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
HCT-116	GI₅₀	0.002 μM Compound: 2b, EPI28265	Growth inhibition of human HCT116 cells after 48 hrs by CellTiter-Glo assay Growth inhibition of human HCT116 cells after 48 hrs by CellTiter-Glo assay	[PMID: 18651728]
HCT-116	EC₅₀	0.002 μM Compound: 6b, EP128265, MPI-0441138	Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 19296653]
HCT-116	EC₅₀	0.002 μM Compound: 2b, EPI28265	Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs	[PMID: 18651728]
HeLa	IC₅₀	0.6 nM Compound: 8	Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
HeLa	IC₅₀	0.6 nM Compound: 8	Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
MDA-MB-435	IC₅₀	0.6 nM Compound: 8	Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SK-OV-3	IC₅₀	0.8 nM Compound: 8	Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SK-OV-3	IC₅₀	1.1 nM Compound: 8	Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]
SNU-398	EC₅₀	0.002 μM Compound: 6b, EP128265, MPI-0441138	Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 19296653]
T47D	GI₅₀	0.001 μM Compound: 2b, EPI28265	Growth inhibition of human T47D cells after 48 hrs by CellTiter-Glo assay Growth inhibition of human T47D cells after 48 hrs by CellTiter-Glo assay	[PMID: 18651728]
T47D	EC₅₀	0.002 μM Compound: 6b, EP128265, MPI-0441138	Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay	[PMID: 19296653]
T47D	EC₅₀	0.002 μM Compound: 2b, EPI28265	Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs	[PMID: 18651728]
U-251	IC₅₀	32.5 nM Compound: 8	Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 33647840]

In Vitro

MPI-0441138 (5 nM; 72 h) idnuces apoptosis and DNA fragmentation in 22Rv1, MDA-MB-231, Caco-2, and Du145 cells^[1].
MPI-0441138 (5 nM; 1 h) induces AIF and cytochrome c translocation from mitochondria to cytosol and nucleus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	22Rv1, MDA-MB-231, Caco-2, and Du145 cells
Concentration:	5 nM
Incubation Time:	12, 24, 48, or 72 h
Result:	Resulted robust caspase-3 activation and poly(ADP-ribose) polymerase cleavage, induced DNA fragmentation.

Molecular Weight

299.75

Formula

C₁₆H₁₄ClN₃O

CAS No.

827030-33-1

SMILES

CN(C1=CC=C(OC)C=C1)C2=C3C=CC=CC3=NC(Cl)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71. [Content Brief]

MPI-0441138 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPI-0441138827030-33-1MPI0441138MPI 0441138ApoptosisDNA breakagenuclear translocationanti-cancerInhibitorinhibitorinhibit

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