Mps1-IN-4

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Data Sheet Handling Instructions Technical Support

Mps1-IN-4 is a selective Monopolar spindle 1 (Mps1) inhibitor with antiproliferative activity for cancer research.

For research use only. We do not sell to patients.

Mps1-IN-4 Chemical Structure

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Description

Mps1-IN-4 is a selective Monopolar spindle 1 (Mps1) inhibitor with antiproliferative activity for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6 nM Compound: 27f	Antiproliferative activity against human A549 cells after 72 hrs by WST8 assay Antiproliferative activity against human A549 cells after 72 hrs by WST8 assay	[PMID: 25625617]
A549	IC₅₀	6 nM Compound: 33	Antiproliferative activity against human A549 cells after 96 hrs by crystal violet staining-bsed FACS analysis Antiproliferative activity against human A549 cells after 96 hrs by crystal violet staining-bsed FACS analysis	[PMID: 31121430]
HCT-116	IC₅₀	9.4 nM Compound: 27f	Antiproliferative activity against human HCT116 cells after 72 hrs by WST8 assay Antiproliferative activity against human HCT116 cells after 72 hrs by WST8 assay	[PMID: 25625617]
HCT-15	IC₅₀	6.3 nM Compound: 27f	Antiproliferative activity against human HCT15 cells after 72 hrs by WST8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by WST8 assay	[PMID: 25625617]
HL-60	IC₅₀	9.1 nM Compound: 27f	Antiproliferative activity against human HL60 cells after 72 hrs by WST8 assay Antiproliferative activity against human HL60 cells after 72 hrs by WST8 assay	[PMID: 25625617]
HT-29	IC₅₀	16 nM Compound: 27f	Antiproliferative activity against human HT-29 cells after 72 hrs by WST8 assay Antiproliferative activity against human HT-29 cells after 72 hrs by WST8 assay	[PMID: 25625617]
LC-2-ad	IC₅₀	17 nM Compound: 27f	Antiproliferative activity against human LC2/ad cells after 72 hrs by WST8 assay Antiproliferative activity against human LC2/ad cells after 72 hrs by WST8 assay	[PMID: 25625617]
LU-99A	IC₅₀	4.7 nM Compound: 27f	Antiproliferative activity against human LU99A cells after 72 hrs by WST8 assay Antiproliferative activity against human LU99A cells after 72 hrs by WST8 assay	[PMID: 25625617]
MIA PaCa-2	IC₅₀	8.1 nM Compound: 27f	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by WST8 assay Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by WST8 assay	[PMID: 25625617]
MKN-45	IC₅₀	3.3 nM Compound: 27f	Antiproliferative activity against human MKN45 cells after 72 hrs by WST8 assay Antiproliferative activity against human MKN45 cells after 72 hrs by WST8 assay	[PMID: 25625617]
MRC5	IC₅₀	> 10000 nM Compound: 27f	Antiproliferative activity against human MRC5 cells after 72 hrs by WST8 assay Antiproliferative activity against human MRC5 cells after 72 hrs by WST8 assay	[PMID: 25625617]
NCI-H358	IC₅₀	320 nM Compound: 27f	Antiproliferative activity against human NCI-H358 cells after 72 hrs by WST8 assay Antiproliferative activity against human NCI-H358 cells after 72 hrs by WST8 assay	[PMID: 25625617]
NCI-H460	IC₅₀	10 nM Compound: 27f	Antiproliferative activity against human NCI-H460 cells after 72 hrs by WST8 assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by WST8 assay	[PMID: 25625617]
PC-14	IC₅₀	9.8 nM Compound: 27f	Antiproliferative activity against human PC14 cells after 72 hrs by WST8 assay Antiproliferative activity against human PC14 cells after 72 hrs by WST8 assay	[PMID: 25625617]

Molecular Weight

516.56

Formula

C₂₆H₃₁F₃N₆O₂

CAS No.

1263423-94-4

SMILES

O=C(NC1CC1)C(C=C2)=CC=C2C3=CN=C4N3N=C(NC(C)(C)C(F)(F)F)C=C4NCC5CCOCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ken-Ichi Kusakabe, et al. Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity. J Med Chem. 2015 Feb 26;58(4):1760-75. [Content Brief]

Mps1-IN-4 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-41263423-94-4Mps1Monopolar spindle 1Inhibitorinhibitorinhibit

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Mps1-IN-4

Mps1-IN-4 Related Antibodies

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Mps1-IN-4 Related Classifications

Molarity Calculator

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