2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Mps1 Apoptosis
  4. Mps1-IN-5

Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage.

For research use only. We do not sell to patients.

Mps1-IN-5 Chemical Structure

Mps1-IN-5 Chemical Structure

CAS No. : 2890819-31-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Mps1-IN-5 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1].

IC50 & Target

IC50: 29 nM (Mps1)[1]
In Vitro

Mps1-IN-5 (compound 12) (0-10 µM,24, 48, 72 h) inhibits the proliferation of MCF-7 and 4T1 cells in a time-dependent manner[1].
Mps1-IN-5 (0, 0.5, 1.0, 5.0 µM; 24, 48 h) induces apoptosis and cell cycle arrests at G2/M phase in a dose-dependent manner in MCF-7 and 4T1 cells[1].
Mps1-IN-5 (0, 0.03, 0.1, 1, 3 µM; 2 h) inhibits phosphorylation of Mps1 and induces DNA damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mps1-IN-5 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, MCF-7, 4T1, HEY, OVCAR-3, ES-2, HCT-116, A549, AGS cells
Concentration: 0-3 µM
Incubation Time: 72 h
Result: Inhibited the cell growth with IC50s of 2.68, 0.37, 0.40, >3, >3, >3, 1.06, 2.03, >3 µM for MDA-MB-231, MCF-7, 4T1, HEY, OVCAR-3, ES-2, HCT-116, A549, AGS cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7, 4T1 cells
Concentration: 0, 0.5, 1.0, 5.0 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest of MCF-7 and 4T1 cells at the G2/M phase in a dose-dependent manner, decreased the protein expression levels of Cyclin B1 and CDK1.

Apoptosis Analysis[1]

Cell Line: MCF-7, 4T1 cells
Concentration: 0, 0.5, 1.0, 5.0 µM
Incubation Time: 48 h
Result: Induced apoptosis and significantly increased the expression level of an apoptosis-related protein, cleaved poly ADP-ribose polymerase (PARP).

Western Blot Analysis[1]

Cell Line: MCF-7, 4T1 cells
Concentration: 0, 0.03, 0.1, 1, 3 µM
Incubation Time: 2 h
Result: Increased the expression of level of γ-H2AX protein and decreased the protein expression of p-Mps1 in a dose-dependent manner.
In Vivo

Mps1-IN-5 (30, 60 mg/kg; p.o.; daily for 15 days) inhibits tumor growth without obvious toxicity in breast cancer models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, female BALB/C mice (4T1-luc mouse xenograft model)[1]
Dosage: 30, 60 mg/kg
Administration: P.o.; daily for 15 days
Result: Significantly suppressed tumor growth and caused negligible damage to organs such as heart, liver, spleen, lung and kidneys.
Molecular Weight

439.52

Formula

C24H25N9
CAS No.
SMILES

CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(N5N=C(C6=CC=CC=C65)N)=N3)C=CN4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Mps1-IN-5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-52890819-31-3Mps1ApoptosisMonopolar spindle 1antiproliferativeanti-tumorMCF-74T1 cellsp-Mps1DNA damageapoptosisG2/M phasebreast cancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Mps1-IN-5
Cat. No.:
HY-151980
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.