2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. MRL-650

MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.

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MRL-650 Chemical Structure

MRL-650 Chemical Structure

CAS No. : 852315-00-5

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Based on 1 publication(s) in Google Scholar

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Description

MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1].

IC50 & Target[1]

CB1

7.5 nM (IC50)

CB2

4100 nM (IC50)

In Vivo

MRL-650 (Compound 14; 0.3, 1, or 3 mg/kg）inhibits feeding in a dose-dependent manner[1].
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 0.3, 1, or 3 mg/kg
Administration: PO
Result: Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.
Molecular Weight

514.79

Formula

C25H18Cl3N3O3
CAS No.
SMILES

CC(NC1=C(C(C)=O)C(N(C)C2=NC(C3=CC=C(Cl)C=C3Cl)=C(C4=CC=C(Cl)C=C4)C=C12)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRL-650 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRL-650852315-00-5CB1 inverse agonist 1MRL650MRL 650Cannabinoid ReceptorCannabinoidCB1InverseagonistAnorexigenicObesityInhibitorinhibitorinhibit

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HY-135280
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