2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. MRL-650

MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.

For research use only. We do not sell to patients.

MRL-650 Chemical Structure

MRL-650 Chemical Structure

CAS No. : 852315-00-5

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Based on 1 publication(s) in Google Scholar

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Description

MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1].

IC50 & Target[1]

CB1

7.5 nM (IC50)

CB2

4100 nM (IC50)

In Vivo

MRL-650 (Compound 14; 0.3, 1, or 3 mg/kg）inhibits feeding in a dose-dependent manner[1].
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 0.3, 1, or 3 mg/kg
Administration: PO
Result: Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.
Molecular Weight

514.79

Formula

C25H18Cl3N3O3
CAS No.
SMILES

CC(NC1=C(C(C)=O)C(N(C)C2=NC(C3=CC=C(Cl)C=C3Cl)=C(C4=CC=C(Cl)C=C4)C=C12)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRL-650 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRL-650852315-00-5CB1 inverse agonist 1MRL650MRL 650Cannabinoid ReceptorCannabinoidCB1InverseagonistAnorexigenicObesityInhibitorinhibitorinhibit

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