MRS2768 tetrasodium salt

Name: MRS2768 tetrasodium salt
Brand: MedChemExpress
SKU: HY-108649A
Rating: 4.5 (1 reviews)

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MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro.

For research use only. We do not sell to patients.

MRS2768 tetrasodium salt Chemical Structure

CAS No. : 2567869-47-8

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro^[1]^[2].

IC₅₀ & Target

P2Y2 Receptor

In Vitro

MRS2768 (0.01-10000 μM; 24 hours) significantly increases the proliferation of PANC-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Human pancreatic duct epithelial cells PANC-1
Concentration:	0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time:	24 hours
Result:	The effect on proliferation of PANC-1 cells was dependent on concentration (0.1 μM to 1 mM). The concentration that elicited a half-maximal response (EC₅₀) in the stimulation of proliferation was 0.8±1.7 μM. Resulted in a dose- and time-dependent increase of proliferation in PANC-1 cells

In Vivo

MRS2768 (4.44 μg/kg i.v.) pretreatment reduces myocardial damage in mice. MRS2768 has a protective effect on cardiomyocytes from ischemic damage in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male wild-type mice (C57BL)^[2]
Dosage:	4.44 μg/kg
Administration:	Injected i.v.; 1 h before myocardial infarct (MI)
Result:	Pretreatment reduced myocardial damage. The damage was significantly smaller in mice compare to the untreated mice (25.6±4.5% vs. 39.2±6.3%).

Molecular Weight

728.14

Formula

C₁₅H₁₆N₂Na₄O₁₈P₄

CAS No.

2567869-47-8

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=P(OP(OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O1)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])OC3=CC=CC=C3

Shipping

Shipping with dry ice.

Storage

-80°C

Purity & Documentation

Data Sheet (274 KB) SDS (251 KB) Handling Instructions (2659 KB)

References

[1]. Ji Hun Choi, et al. Uridine Triphosphate Increases Proliferation of Human Cancerous Pancreatic Duct Epithelial Cells by Activating P2Y2 Receptor. Pancreas. 2013 May;42(4):680-6. [Content Brief]

[2]. Edith Hochhauser, et al. P2Y2 Receptor Agonist With Enhanced Stability Protects the Heart From Ischemic Damage in Vitro and in Vivo. Purinergic Signal. 2013 Dec;9(4):633-42. [Content Brief]