2. GPCR/G Protein
  3. P2Y Receptor
  4. MRS4833

MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with IC50=5.92 nM for hP2Y14R and IC50=4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.

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MRS4833 Chemical Structure

MRS4833 Chemical Structure

CAS No. : 2801627-78-9

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MRS4833 Related Antibodies

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Description

MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with IC50=5.92 nM for hP2Y14R and IC50=4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model[1].

IC50 & Target[1]

hP2Y14R

5.92 nM (IC50)

mP2Y14R

4.8 nM (IC50)

Molecular Weight

503.51

Formula

C30H24F3NO3
CAS No.
SMILES

O[C@@]1(C2=CC=C(C3=CC(C(O)=O)=CC4=C3C=CC(C5=CC=C(C=C5)C(F)(F)F)=C4)C=C2)[C@]6([H])C[C@@]1([H])CNC6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRS4833 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS48332801627-78-9MRS 4833MRS-4833P2Y ReceptorOral activeasthmachronic nerve painantagonistInhibitorinhibitorinhibit

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