MRS5698 

MRS5698 is a selective G_i protein-coupled A₃ adenosine receptor (A₃AR) agonist, with K_is of approximately 3 nM for human and mouse A₃AR, respectively. MRS5698 can be used for the research of pain and psoriasis^[1][2].

MRS5698 displays higher affinity and selectivity (>3000-fold) agonist A₃R vs. other adenosine receptor (ARs) in both human and mouse^[1].
MRS5698 (0.1-10 µM; 1 hours) induces a concentration-dependently robust A3R-mediated cAMP reduction in HEK-293T cells permanently expressing the A3R, regardless the illumination condition^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRS5698 (3 nmol/day; intrathecal injection for 25 days) prevents Oxaliplatin-induced mechano-allodynia and hyperalgesia, and attenuates Oxaliplatin-induced NLRP3/IL-1β neuroinflammation^[2].
MRS5698 (1 mg/kg; i.p. at days 2, 3 ) reduces the IL-23 induced (IL23 injected in day 0, 1, 3) ear thickness of C57BL/6N mouse during the third and fourth experimental days^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

564.97

C₂₈H₂₃ClF₂N₆O₃

1377273-00-1

CNC([C@]12[C@]([C@](N3C4=NC(C#CC5=CC(F)=C(C=C5)F)=NC(NCC6=CC(Cl)=CC=C6)=C4N=C3)([H])[C@@H]([C@@H]2O)O)([H])C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tosh DK, et al. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 2015;11(3):371-387.  [Content Brief]

  [2]. Wahlman C, et al. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms. Pain. 2018;159(6):1025-1034.  [Content Brief]

  [3]. López-Cano M, et al. Optical control of adenosine A3 receptor function in psoriasis. Pharmacol Res. 2021 Aug;170:105731.  [Content Brief]