MS182

Cat. No.: HY-159606: FAQs
Data Sheet Handling Instructions

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MS182 (compound 11) is an acetylation targeting chimera (AceTAC) designed based on p53^Y220C stabilizer and targeting p53^Y220C. MS182 is composed of p53^Y220C and p300/CBP binders, respectively, coupled by a linker. MS182 forms a ternary complex with p300/CBP acetyltransferase and p53^Y220C in a time- and concentration-dependent manner, effectively acetylating lysine at position 382 of p53^Y220C (ACE₅₀: 1.52 μM). MS182 also exhibited considerable bioavailability in mice, with GI₅₀ values of 2.16 μM and 1.83 μM for BxPC3 (p53^Y220C/-) and NUGC (p53^Y220C/+), respectively.

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MS182 Chemical Structure

CAS No. : 3034773-62-8

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Description	MS182 (compound 11) is an acetylation targeting chimera (AceTAC) designed based on p53^Y220C stabilizer and targeting p53^Y220C. MS182 is composed of p53^Y220C and p300/CBP binders, respectively, coupled by a linker. MS182 forms a ternary complex with p300/CBP acetyltransferase and p53^Y220C in a time- and concentration-dependent manner, effectively acetylating lysine at position 382 of p53^Y220C (ACE₅₀: 1.52 μM). MS182 also exhibited considerable bioavailability in mice, with GI₅₀ values of 2.16 μM and 1.83 μM for BxPC3 (p53^Y220C/-) and NUGC (p53^Y220C/+), respectively^[1].
IC₅₀ & Target	ACE50: 1.52 μM (p53^Y220C)^[1]
Molecular Weight	1014.26
Formula	C₅₇H₆₈FN₇O₇S
CAS No.	3034773-62-8
SMILES	O=C(NCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1F)CCOCCOCCOCCNCC6=CC7=C(C=C6)N(CC)C8=C7C=CC(C9=CC(C)=CS9)=C8
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)

MS182 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS1823034773-62-8MS 182MS-182MDM-2/p53Inhibitorinhibitorinhibit

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MS182

MS182 Related Antibodies

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