2. GPCR/G Protein
  3. TSH Receptor
  4. MS437

MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions.

For research use only. We do not sell to patients.

MS437 Chemical Structure

MS437 Chemical Structure

CAS No. : 541535-31-3

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Based on 1 publication(s) in Google Scholar

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Description

MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions[1].

Molecular Weight

332.44

Formula

C22H24N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C(C=CC=C2)=NC(C3=CC=CC=C3)=C1)N(C(C)C)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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MS437 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS437541535-31-3MS 437MS-437TSH ReceptorThyrotropin receptorThyroid-stimulating hormone ReceptorTSHRGsαGαqGα12TgNISInhibitorinhibitorinhibit

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HY-114994
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