2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. PROTACs EGFR
  4. MS9449

MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer.

For research use only. We do not sell to patients.

MS9449 Chemical Structure

MS9449 Chemical Structure

CAS No. : 2772612-96-9

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1 mg USD 540 In-stock
5 mg USD 1350 In-stock
10 mg USD 2150 In-stock
25 mg USD 4250 In-stock
50 mg USD 6800 In-stock
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Based on 1 publication(s) in Google Scholar

MS9449 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer[1].

IC50 & Target[1]

EGFR (WT)

17 nM (Kd)

EGFR L858R

10 nM (Kd)

Molecular Weight

1151.82

Formula

C60H76ClFN10O8S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@H]1N(C([C@@H](C2=CC(C)=NO2)C(C)C)=O)C[C@H](O)C1)N[C@H](C3=CC=C(C4=C(C)N=CS4)C=C3)CC(NCCCCCCCCCCC(N5CCN(CCCOC6=CC7=C(NC8=CC=C(F)C(Cl)=C8)N=CN=C7C=C6OC)CC5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (173.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8682 mL 4.3410 mL 8.6819 mL
5 mM 0.1736 mL 0.8682 mL 1.7364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8682 mL 4.3410 mL 8.6819 mL 21.7048 mL
5 mM 0.1736 mL 0.8682 mL 1.7364 mL 4.3410 mL
10 mM 0.0868 mL 0.4341 mL 0.8682 mL 2.1705 mL
15 mM 0.0579 mL 0.2894 mL 0.5788 mL 1.4470 mL
20 mM 0.0434 mL 0.2170 mL 0.4341 mL 1.0852 mL
25 mM 0.0347 mL 0.1736 mL 0.3473 mL 0.8682 mL
30 mM 0.0289 mL 0.1447 mL 0.2894 mL 0.7235 mL
40 mM 0.0217 mL 0.1085 mL 0.2170 mL 0.5426 mL
50 mM 0.0174 mL 0.0868 mL 0.1736 mL 0.4341 mL
60 mM 0.0145 mL 0.0723 mL 0.1447 mL 0.3617 mL
80 mM 0.0109 mL 0.0543 mL 0.1085 mL 0.2713 mL
100 mM 0.0087 mL 0.0434 mL 0.0868 mL 0.2170 mL
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MS9449 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS94492772612-96-9MS 9449MS-9449PROTACsEGFREpidermal growth factor receptorErbB-1HER1anticancerantiproliferativeNSCLCUPSautophagy/lysosome pathwayInhibitorinhibitorinhibit

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