MT-7

Cat. No.: HY-122249: FAQs
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MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules.

For research use only. We do not sell to patients.

MT-7 Chemical Structure

CAS No. : 946507-08-0

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1.8 μM Compound: 1a (MT-7)	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 24360827]

In Vitro

MT-7 (0-8µM; 72 h) inhibits cell proliferation with IC₅₀ values ranging from 0.85 μM to 5.01 μM for HeLa, HL60, A549,MDA-MB-468, Lovo, HCT116, SMMC-7721, HO-8910, A375 and SG7901 cells^[1].
MT-7 (5 μM; 12 h) induces cell cycle arrest at the G2/M phase^[1].
MT-7 (5 μM; 1.5, 3, 6, 12 h) increases the gene expression of THBS, IL6 and PHLDA1, dereases the gene expression of COX5B, RPS11 and CYP26A1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	HeLa cells
Concentration:	5 μM
Incubation Time:	12 h
Result:	Induced cell cycle arrest at G2/M phase and decreased the protein expression of MPM-2, Pi-H3.

RT-PCR^[1]

Cell Line:	HeLa cells
Concentration:	5 μM
Incubation Time:	1.5, 3, 6, 12 h
Result:	Upregulated the gene expression of THBS, IL6 and PHLDA1, doen-regulated the gene expression of COX5B, RPS11 and CYP26A1.

Molecular Weight

355.39

Formula

C₂₂H₁₇N₃O₂

CAS No.

946507-08-0

SMILES

O=C1N(C2=C(C3=C1C=CC=C3)N=C4N2C=CC=C4)CC5=CC=C(C=C5)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Z, et al. MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules. Invest New Drugs. 2010 Dec;28(6):715-28. [Content Brief]

MT-7 Related Classifications

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-7946507-08-0MT7MT 7Microtubule/TubulinHeLa cellsG2/M phaseMPM-2Pi-H3THBSInhibitorinhibitorinhibit

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