MT-7716 free base (Synonyms: W-212393)

Cat. No.: HY-107094A: FAQs
Data Sheet Handling Instructions

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MT-7716 free base (W-212393) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention.

For research use only. We do not sell to patients.

MT-7716 free base Chemical Structure

CAS No. : 610323-32-5

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Other Forms of MT-7716 free base:

MT-7716 hydrochloride Get quote

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•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

MT-7716 free base (W-212393) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention^[1].

IC₅₀ & Target

NOP Receptor/ORL1

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1.6 nM Compound: 1, W-212393	Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay	[PMID: 22541041]

Molecular Weight

440.54

Formula

C₂₇H₂₈N₄O₂

CAS No.

610323-32-5

SMILES

O=C(CN(C1=O)C2=CC=CC=C2N1C3CCN(CC3)[C@@H]4CC5=C6C4=CC=CC6=CC=C5)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. de Guglielmo G, et al, MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats. Addict Biol. 2015 Jul;20(4):643-51. [Content Brief]

MT-7716 free base Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-7716610323-32-5W-212393MT7716MT 7716W212393W 212393Opioid ReceptorInhibitorinhibitorinhibit

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